Following an opening chapter by the late Susumu Ohno on paralogues of sex-determining genes, the five best-studied genes essential for early mammalian gonadal development are portrayed in detail: SF-1 and WT1 and their roles in early events in gonadal development, SRY and SOX9 in testis determination, and the anti-testis gene DAX-1. Subsequent chapters look at the roles of these genes in sex determination in marsupial mammals, birds, reptiles, amphibians and fish, and review the different sex-determining mechanisms, genetic and environmental, that operate in these different vertebrate classes. Two insights emerge: one, that the same basic set of genes appears to operate during early gonadal development in all vertebrates, despite the differences in mechanisms; the other, that sex determination in vertebrates results from a complex network of regulatory interactions and not from a simple hierarchical cascade of gene actions.
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Following an opening chapter by the late Susumu Ohno on paralogues of sex-determining genes, the five best-studied genes essential for early mammalian gonadal development are portrayed in detail: SF-1 and WT1 and their roles in early events in gonadal development, SRY and SOX9 in testis determination, and the anti-testis gene DAX-1. Subsequent chapters look at the roles of these genes in sex determination in marsupial mammals, birds, reptiles, amphibians and fish, and review the different sex-determining mechanisms, genetic and environmental, that operate in these different vertebrate classes. Two insights emerge: one, that the same basic set of genes appears to operate during early gonadal development in all vertebrates, despite the differences in mechanisms; the other, that sex determination in vertebrates results from a complex network of regulatory interactions and not from a simple hierarchical cascade of gene actions.
Imprint | Birkhauser Verlag AG |
Country of origin | Switzerland |
Series | Experientia Supplementum, 91 |
Release date | October 2013 |
Availability | Expected to ship within 10 - 15 working days |
First published | 2001 |
Editors | Gerd Scherer, Michael Schmid |
Dimensions | 244 x 170 x 11mm (L x W x T) |
Format | Paperback |
Pages | 205 |
Edition | Softcover reprint of the original 1st ed. 2001 |
ISBN-13 | 978-3-03-487783-1 |
Barcode | 9783034877831 |
Categories | |
LSN | 3-03-487783-8 |