The characterization of the genetic variations of the PON1 gene together withexperiments showing that HDL can protect the lipids in low density lipoprotein particles (LDL) from oxidation and that it was PON1 that was responsible for this protection have opened an entirely new area of investigation, the role of PON1 in protecting against vascular disease.
More recent reports have noted that PON1 also metabolizes a number of drugs, activating some and inactivating others.
This book describes the recent advances in understanding the role of PON1 in both cardiovascular disease and toxicology of insecticide exposure as well as some of the recent information indicating an important possible role in the pharmacokinetics of drug metabolism. The final chapter of the book provides an overview of the areas of PON1 research and suggests future directions for research on PON1 as well as the related, linked genes PON2 and PON3.
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The characterization of the genetic variations of the PON1 gene together withexperiments showing that HDL can protect the lipids in low density lipoprotein particles (LDL) from oxidation and that it was PON1 that was responsible for this protection have opened an entirely new area of investigation, the role of PON1 in protecting against vascular disease.
More recent reports have noted that PON1 also metabolizes a number of drugs, activating some and inactivating others.
This book describes the recent advances in understanding the role of PON1 in both cardiovascular disease and toxicology of insecticide exposure as well as some of the recent information indicating an important possible role in the pharmacokinetics of drug metabolism. The final chapter of the book provides an overview of the areas of PON1 research and suggests future directions for research on PON1 as well as the related, linked genes PON2 and PON3.
Imprint | Springer-Verlag New York |
Country of origin | United States |
Release date | November 2002 |
Availability | Expected to ship within 10 - 15 working days |
First published | 2002 |
Editors | Lucio G. Costa, Clement E. Furlong |
Dimensions | 235 x 155 x 14mm (L x W x T) |
Format | Hardcover |
Pages | 216 |
Edition | 2002 ed. |
ISBN-13 | 978-1-4020-7282-6 |
Barcode | 9781402072826 |
Categories | |
LSN | 1-4020-7282-1 |