Polymeric Dispersions of Highly Water Soluble Drug (Paperback)

Extended release of solid dispersion of water soluble PHC was successively prepared by coevaporation with Eudragit RLPO in 1: 5 ratios. The sustainment of drug release was effected by drug-polymer ratio and method of preparation. The analysis by spectral techniques (FT-IR, FT-NMR) suggested possibility of hydrogen bonding. The results of DSC, XRD and SEM studies revealed the reduction in crystallinity of pure drug in solid dispersions as compared to their physical mixtures. The results of solubility studies were in accordance with the in vitro release profile and the order of sustainment of drug release was found in rank order of 0.1 N HCl (pH 1.2)